NFL players who experienced concussion symptoms during careers show
reduced cognitive performance decades after retirement

Date:
March 3, 2023
Source:
Mass General Brigham
Summary:
More than 350 former NFL players were studied on average 29
years after their playing careers ended. Retirees who experienced
concussion symptoms during their playing careers were found to
perform worse on a battery of cognitive tests. When comparing the
retired players to more than 5,000 men who did not play football,
cognitive performance was generally worse for former players,
with older players performing worse.


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FULL STORY ========================================================================== Former professional football players who reported experiencing concussion symptoms during their playing careers were found to perform worse on
a battery of cognitive tests than non-players, according to a study
led by Mass General Brigham investigators from McLean Hospital and
Spaulding Rehabilitation Network. Results of the study are published
March 2ndinArchives of Clinical Neuropsychology.


==========================================================================
Of the more than 350 former National Football League (NFL) players who
were studied an average of 29 years after their playing career ended,
those who reported experiencing concussion symptoms during their careers
scored worse on assessments of episodic memory, sustained attention,
processing speed and vocabulary. However, the number of concussions
diagnosed by a medical professional or length of playing career had no
observed effect on cognition.

A follow-up analysis compared the former players to more than 5,000
male volunteers in the general population who did not play professional football, which found that cognitive performance was generally worse for
former players than nonplayers. While younger former players outperformed nonplayers on some tests, older retired players more likely to perform
worse than controls on cognitive tasks.

The researchers who led the study said that their results underline
the importance of tracking concussion symptoms as opposed to diagnosed concussions in research. This work also adds evidence to the impact a professional football career can have on accelerating cognitive aging.

"It is well-established that in the hours and days after a concussion,
people experience some cognitive impairment. However, when you look
decades out, the data on the long-term impact have been mixed," said study senior author Laura Germine, PhD, director of the Laboratory for Brain and Cognitive Health Technology at McLean Hospital and associate professor
of psychiatry at Harvard Medical School. "These new findings from the
largest study of its kind show that professional football players can
still experience cognitive difficulties associated with head injuries
decades after they have retired from the sport." Concussion Symptoms
Linked to Cognitive Performance For the study, 353 retired NFL players completed hour-long neuropsychological tests through an online platform
called TestMyBrain, which is supported by McLean Hospital and Harvard
Medical School. Players were fully remote and completed tests on a laptop
or desktop that included assessments that measured processing speed, visual-spatial and working memory, and aspects of short- and long-term
memory and vocabulary.

Recollected concussion symptoms were measured by asking the players
the number of times they experienced any one of the following symptoms following a blow to the head during play or practice: headaches, nausea, dizziness, loss of consciousness, memory problems, disorientation,
confusion, seizure, visual problems or feeling unsteady on their
feet. They were also asked whether they lost consciousness during their careers, and whether they were ever diagnosed with a concussion by a
medical professional.

The results showed that the former players' cognitive performance
(for example, on memory tasks) was associated with recalled football
concussion symptoms. For example, differences observed in visual memory
scores between former players with the highest and lowest reported
concussion symptoms were equivalent to the differences in cognitive
performance between a typical 35-year-old and 60-year- old.

However, poor cognitive performance was not associated with diagnosed concussions, years of professional play or age of first football
exposure. The researchers noted that many head injuries or sub-concussive
blows may not have been diagnosed as concussions due to a lack of
awareness at the time or underreporting of symptoms by players.

When comparing the retired players to a group of 5,086 men who did not
play football, cognitive performance was generally worse for former
players. On two tests of processing speed, age-related differences in
cognitive performance were larger among the former player group than
the nonplayer group, with older players performing worse.

These comparison data suggest that football exposure might accelerate
age- related cognitive declines and produce greater disadvantages at
older ages, according to the researchers, who added that more studies
are needed to track cognitive performance in former players as they
age. Another possibility is that improved awareness and management of
head injuries may have spared younger retired players more than older
ones. The researchers also noted that this comparative finding is limited
by a lack of data on cognition prior to head injuries, and that more
research is needed that closely matches former players and nonplayers
and measures their cognitive performances across their lifetimes.

"For both former players and researchers, we can glean some important
takeaways from this study," said principal investigator of the Football
Players Health Study, Ross Zafonte, DO. "Former players can support their cognitive health as they age by taking proactive steps, and continuing to consult with their providers and educate themselves on symptoms of head
injury. For researchers and providers, these findings support efforts
to develop ways to enhance diagnosis and define long-term sequalae of concussion." Zafonte is president of Spaulding Rehabilitation Network, a
Mass General Brigham sports medicine physician, and the Earle P. and Ida
S. Charlton Professor and Chair of the Harvard Medical School Department
of Physical Medicine and Rehabilitation.

"The Community Based Participatory Research (CBPR) approach taken in this
study is where this field is heading," said Germine. "We are grateful
to the players and how much they have taught us. It would not have been possible to do a study like this without engaging and deeply involving
their community." Research Driven by Input from Former NFL Players
The Football Players Health Study at Harvard University, launched in
2014, is a comprehensive research program dedicated to examining the multifactorial causes that impact the health of former NFL players. The research has been informed by the players themselves, who have provided
input on the health concerns and conditions they face after a career in football. An interdisciplinary team of researchers from Harvard University
and Harvard Medical School and its affiliated teaching hospitals,
including those in the Mass General Brigham system, conduct research
from neurology, cardiology, sports medicine, rehabilitation medicine,
chronic pain and public health. While concussion and head injury are
of paramount concern, the study examines all aspects of player health
across the life span. Former players can find important resources to
support their health in this section of the study's website.

* RELATED_TOPICS
o Health_&_Medicine
# Sports_Medicine # Healthy_Aging #
Diseases_and_Conditions # Accident_and_Trauma
o Mind_&_Brain
# Intelligence # Brain_Injury # Dementia # Behavior
* RELATED_TERMS
o Runner's_knee o Soccer o Hair o Attention o Tennis_elbow o
The_evolution_of_human_intelligence o Cognitive_neuroscience
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========================================================================== Story Source: Materials provided by Mass_General_Brigham. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Roger W Strong, Rachel Grashow, Andrea L Roberts, Eliza Passell,
Luke
Scheuer, Douglas P Terry, Sarah Cohan, Alvaro Pascual-Leone,
Marc G Weisskopf, Ross D Zafonte, Laura T Germine. Association
of Retrospectively Reported Concussion Symptoms with Objective
Cognitive Performance in Former American-Style Football
Players. Archives of Clinical Neuropsychology, 2023; DOI:
10.1093/arclin/acad008 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/03/230303105233.htm

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