New antioxidants found in beef, chicken, and pork
Establishment of a highly sensitive detection method for imidazole
dipeptide oxidation derivatives

Date:
February 17, 2023
Source:
Osaka Metropolitan University
Summary:
Scientists found that 2-oxo-imidazole-containing dipeptides
(2-oxo-IDPs) exhibit very high antioxidant activity. Furthermore,
they established a method to selectively and sensitively detect
very small amounts of 2-oxo- IDPs and revealed for the first time
that several types of 2-oxo-IDPs are contained in meat, including
beef, pork, and chicken.


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FULL STORY ========================================================================== Imidazole dipeptides (IDPs), which are abundant in meat and fish,
are substances produced in the bodies of various animals, including
humans, and have been reported to be effective in relieving fatigue and preventing dementia. However, the physiological mechanism by which IDPs
exhibit these activities had not been determined previously.


==========================================================================
A research team, led by Professor Hideshi Ihara from the Osaka
Metropolitan University Graduate School of Science, was the first to
discover 2-oxo- imidazole-containing dipeptides (2-oxo-IDPs) -- which
have one more oxygen atom than normal IDPs -- and found that they are
the most common variety of IDPs derivatives in the body. The researchers
also found that they have remarkably high antioxidant activity.

In their study, the researchers established a method for selective
and highly sensitive detection of five types of 2-oxo-IDPs using mass spectrometry, which enables quantitative detection of trace 2-oxo-IDPs
in living organisms. Using this method, they revealed for the first
time that beef, pork, chicken, and other meats contain antioxidants,
not only IDPs but a variety of different 2- oxo-IDPs. Their findings
were published in Antioxidants.

"We hope that this research method, which enables advanced analysis
of 2-oxo- IDPs, will be applied not only to basic biology but also to
medicine, agriculture, and pharmacy, where it will help improve peoples'
health and prevent diseases," concluded Professor Ihara.

* RELATED_TOPICS
o Health_&_Medicine
# Pain_Control # Medical_Topics # Vegetarian #
Diseases_and_Conditions
o Plants_&_Animals
# Cows,_Sheep,_Pigs # Soil_Types # Biology # Wild_Animals
* RELATED_TERMS
o Hereford_(cattle) o Meat_analogue o Beef o Food_groups o
Glycogen o Pig o Health_benefits_of_tea o Mustang_horse

========================================================================== Story Source: Materials provided by Osaka_Metropolitan_University. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Somei Komae, Shingo Kasamatsu, Koji Uchida, Hideshi
Ihara. Quantitative
Determination of 2-Oxo-Imidazole-Containing Dipeptides
by High- Performance Liquid Chromatography/Tandem Mass
Spectrometry. Antioxidants, 2022; 11 (12): 2401 DOI:
10.3390/antiox11122401 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/02/230217081439.htm

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