Do older adults using statins have lower risk of developing Parkinsonism later?
Study finds drug therapy associated with 16% lower risk

Date:
March 23, 2022
Source:
American Academy of Neurology
Summary:
Parkinsonism is a term for a group of neurological conditions that
cause movement problems including tremors, slowed movement and
stiffness, with Parkinson's disease being one of the better knowns
causes. A new study suggests that older people taking statin drugs
have a lower chance of developing parkinsonism later compared to
people who were not taking statins.



FULL STORY ========================================================================== Parkinsonism is a term for a group of neurological conditions that cause movement problems including tremors, slowed movement and stiffness,
with Parkinson's disease being one of the better knowns causes. A
new study suggests that older people taking statin drugs have a lower
chance of developing parkinsonism later compared to people who were not
taking statins. The research is published in the March 23, 2022, online
issue of Neurology(R), the medical journal of the American Academy of Neurology. Statins are drugs used to lower cholesterol in the blood and
protect against atherosclerosis, a buildup of plaque in the arteries
that can lead to hardening of the arteries, heart attack and stroke.


==========================================================================
"Our results suggest people using statins may have a lower risk of
parkinsonism and that may be partly caused by the protective effect
statins may have on arteries in the brain," said study author Shahram Oveisgharan, MD, of Rush University Medical Center in Chicago. "Our
results are exciting, because movement problems in older adults that come
under the umbrella of parkinsonism are common, often debilitating and
generally untreatable." The study looked 2,841 people with an average
age of 76 who did not have parkinsonism at the start of the study. Of
those, 936 people, or 33%, were taking statins.

Researchers followed up with participants annually for an average of
six years to check the statins they were taking and to test for signs
of parkinsonism.

People were considered to have parkinsonism if they met the requirement
for mild impairment for two or more of the following symptoms: tremor, stiffness, parkinsonian gait, which is marked by small shuffling steps
and a general slowness of movement, and bradykinesia, a hallmark of parkinsonism which is difficulty moving the body quickly on command.

By the end of the study, 1,432 people, or 50%, developed signs of
parkinsonism.

Out of 936 people taking statins, 418 people, or 45%, developed
parkinsonism six years later, compared to 1,014 out of 1,905 people,
or 53%, of those who had not been taking statins.

After controlling for age, sex and vascular risks like smoking and
diabetes that could affect risk of parkinsonism, researchers found that
people who had been taking statins, on average, had 16% lower risk of developing parkinsonism six years later compared to those who had not
been taking statins. About 79% of people on statin therapy were taking
moderate or high intensity statins.

Researchers found that people taking higher intensity statins had a 7%
lower risk of developing parkinsonism compared to those on low intensity statins.

Researchers also examined the brains of 1,044 people who died during
the study.

They found those who had been using statins had, on average, 37% lower
odds of having atherosclerosis compared to those who had not been using statins.

"More research is needed, but statins could be a therapeutic option in
the future to help reduce the effects of parkinsonism in the general
population of older adults, not just people with high cholesterol or
who are at risk for stroke," Oveisgharan said. "At a minimum, our study suggests brain scans or vascular testing may be beneficial for older
adults who show signs of parkinsonism but don't have classic signs of Parkinson's disease or do not respond to Parkinson's disease medications."
A limitation of the study is that parkinsonism evaluations were not
performed by movement disorder specialists, so cases of Parkinson's
disease may have been misclassified.

The study was supported by the National Institutes of Health.


========================================================================== Story Source: Materials provided by American_Academy_of_Neurology. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Shahram Oveisgharan, Lei Yu, Lisa L. Barnes, Sonal Agrawal, Julie A.

Schneider, David a Bennett, Aron S. Buchman. Association of
Statins With Cerebral Atherosclerosis and Incident Parkinsonism
in Older Adults.

Neurology, 2022 DOI: 10.1212/WNL.0000000000200182 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/03/220323160653.htm

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