Hepatitis E virus defies alcohol-based hand disinfectants

Date:
February 1, 2022
Source:
Ruhr-University Bochum
Summary:
The hepatitis E virus (HEV) can cause serious liver inflammation
and is the most common cause of acute virus-mediated hepatitis
worldwide.

Infection can be prevented through appropriate hygiene measures.

Scientists have investigated the effectiveness of various common
hand disinfectants against HEV. They were able to show that most
formulations do not completely inactivate the virus.



FULL STORY ==========================================================================
The hepatitis E virus (HEV) can cause serious liver inflammation
and is the most common cause of acute virus-mediated hepatitis
worldwide. Infection can be prevented through appropriate hygiene
measures. Scientists from TWINCORE, Centre for Experimental and Clinical Infection Research, the Hannover Medical School (MHH) and the Ruhr
Universita"t Bochum (RUB), together with partners from industry, have investigated the effectiveness of various common hand disinfectants
against HEV. They were able to show that most formulations do not
completely inactivate the virus.


==========================================================================
They have now published these results in the Journal of Hepatology from
24 january 2022.

Infection from pork In Germany and Europe, HEV has its natural reservoir
in pigs. The infection can spread from animals to humans, which is called
a zoonosis. This often happens through incompletely heated or raw meat
products such as minced meat. In tropical regions of the world, infections occur via contaminated water, sometimes causing large outbreaks. "Some
of these infections could possibly be prevented with the right hygiene measures," says Dr. Patrick Behrendt, physician in the Department of Gastroenterology, Hepatology and Endocrinology at the MHH and head of the junior research group "Translational Virology" at TWINCORE. This includes, above all, correct hygienic hand disinfection in everyday clinical
practice when dealing with hepatitis E patients and infected animals.

Together with the team of Professor Eike Steinmann, head of the
Department of Molecular and Medical Virology at RUB, Behrendt has
investigated whether common hand disinfectants can render the virus
harmless. "We tested the effect of the alcohols ethanol and propanol,
both individually and in the mixing ratios recommended by the WHO,
and also commercial hand disinfectants," says Steinmann. "However, only
one product that contained another component was effective." Alcohol
alone is not effective Normally, HEV occurs non-enveloped and, like all non-enveloped viruses, is very resistant to chemical influences. However,
virus particles circulating in the blood of patients are surrounded by a
lipid envelope. "Not all disinfectants are effective against enveloped
and non-enveloped viruses at the same time," says Steinmann. "We used
both forms of HEV for our tests." Although some of the disinfectants
tested are certified to inactivate both enveloped and non-enveloped
viruses, they were not sufficiently effective against HEV. "The alcoholic components dissolve the lipid envelope, but the resulting "naked" viruses
are still infectious," says Behrendt. So HEV is literally hard to break
down. The decisive advantage was a product that contains phosphoric acid
as well as alcohol. This neutralised all the virus particles sufficiently.

"We were able to show that HEV can resist most common hand disinfectants,"
says Behrendt. "We hope that these findings will be taken into
consideration in the future when hygiene measures are recommended for
handling contaminated meat products and in HEV outbreak situations." ========================================================================== Story Source: Materials provided by Ruhr-University_Bochum. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Patrick Behrendt, Martina Friesland, Jan-Erik Wissmann, Volker
Kinast,
Yannick Stahl, Dimas Praditya, Lucas Hueffner, Pia Maria No"renberg,
Birgit Bremer, Benjamin Maasoumy, Jochen Steinmann, Britta
Becker, Dajana Paulmann, Florian H.H. Brill, Joerg Steinmann,
Rainer G. Ulrich, Yannick Bru"ggemann, Heiner Wedemeyer, Daniel
Todt, Eike Steinmann. Hepatitis E virus is highly resistant to
alcohol-based disinfectants. Journal of Hepatology, 2022; DOI:
10.1016/j.jhep.2022.01.006 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/02/220201115219.htm

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