Obesity may increase risk of some female reproductive disorders

Date:
February 1, 2022
Source:
PLOS
Summary:
Obesity is associated with an increased risk of developing female
reproductive disorders, however, the roles and mechanisms of
obesity in the cause(s) of reproductive conditions are unclear. A
study suggests an etiological link between obesity and a range
of female reproductive conditions, but the extent of this link
differs among conditions.



FULL STORY ========================================================================== Obesity is associated with an increased risk of developing female
reproductive disorders, however, the roles and mechanisms of obesity in
the cause(s) of reproductive conditions are unclear. A study publishing February 1st inPLOS Medicine by Samvida Venkatesh at University of
Oxford, United Kingdom and colleagues suggests an etiological link
between obesity and a range of female reproductive conditions, but the
extent of this link differs among conditions.


========================================================================== Female reproductive disorders are common conditions affecting the health
and well-being of many. However, the role of obesity in the development
of female reproductive conditions is under-studied. To investigate the
causal associations between obesity, metabolic hormones, and female reproductive disorders, researchers conducted a Mendelian randomization
study of 257,193 women of European ancestry aged 40-69. They accessed
records from UK Biobank, a large-scale biomedical database containing
the medical, environmental, and genetic information of participants. The researchers then created a statistical model to estimate the association
of body mass index and waist-to-hip ratio with risk of numerous female reproductive conditions including endometriosis, heavy menstrual bleeding, pre-eclampsia, and infertility.

The researchers found observational associations between obesity
and a range of female reproductive disorders, including uterine
fibroids, polycystic ovary syndrome, heavy menstrual bleeding, and pre-eclampsia. They also found that some inherited genetic variation
associated with obesity is also associated with female reproductive
disorders, but the strength of those associations differed by type of
obesity and reproductive condition. The study had several limitations,
such as the low prevalence of female reproductive disorders among
participants, and a lack of body mass index and waist-hip-ratio data
prior to disease onset.

According to the authors, "We provide genetic evidence that both
generalised and central obesity play an aetiological role in a broad
range of female reproductive conditions, but the extent of this
link differs substantially between conditions. Our results suggest a
need to explore the mechanisms mediating the causal associations of
overweight and obesity on gynaecological health to identify targets
for disease prevention and treatment." special promotion Get a free
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things we always get wrong about diet and exercise. Claim_yours_now_>>> ========================================================================== Story Source: Materials provided by PLOS. Note: Content may be edited
for style and length.


========================================================================== Journal Reference:
1. Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir,
Nilufer
Rahmioglu, Christian M. Becker, Ingrid Granne, Krina
T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura
B. L. Wittemans. Obesity and risk of female reproductive conditions:
A Mendelian randomisation study. PLOS Medicine, 2022; 19 (2):
e1003679 DOI: 10.1371/ journal.pmed.1003679 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/02/220201143924.htm

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