• Researchers discover new way to target s

    From ScienceDaily@1:317/3 to All on Fri Jan 28 21:30:36 2022
    Researchers discover new way to target secondary breast cancer that has
    spread to the brain

    Date:
    January 28, 2022
    Source:
    RCSI
    Summary:
    A study has revealed a potential new way to treat secondary breast
    cancer that has spread to the brain, using existing drugs.



    FULL STORY ==========================================================================
    A study led by researchers at RCSI University of Medicine and Health
    Sciences and the Beaumont RCSI Cancer Centre (BRCC) has revealed a
    potential new way to treat secondary breast cancer that has spread to
    the brain, using existing drugs.


    ==========================================================================
    The study, published in Nature Communications, was funded by Breast
    Cancer Ireland with support from Breast Cancer Now and Science Foundation Ireland.

    Most breast cancer related deaths are a result of treatment relapse
    leading to spread of tumours to many organs around the body. When
    secondary breast cancer, also known as metastatic breast cancer, spreads
    to the brain it can be particularly aggressive, sometimes giving patients
    just months to live.

    The RCSI study focused on genetically tracking the tumour evolution from diagnosis of primary breast to the metastatic spread in the brain in
    cancer patients. The researchers found that almost half of the tumours
    had changes in the way they repair their DNA, making these tumours
    vulnerable to an existing type of drug known as a PARP inhibitor. PARP inhibitor drugs work by preventing cancer cells to repair their DNA,
    which results in the cancer cells dying.

    "There are inadequate treatment options for people with breast cancer
    that has spread to the brain and research focused on expanding treatment options is urgently needed. Our study represents an important development
    in getting one step closer to a potential treatment for patients with
    this devastating complication of breast cancer," commented Professor
    Leonie Young, the study's Principal Investigator.

    "By uncovering these new vulnerabilities in DNA pathways in brain
    metastasis, our research opens up the possibility of novel treatment
    strategies for patients who previously had limited targeted therapy
    options," said study author Dr Damir Vareslija.

    The research, led by Beaumont RCSI Cancer Centre investigators Professor
    Leonie Young, Dr Nicola Cosgrove, Dr Damir Vareslija and Professor
    Arnold Hill, was carried out in collaboration with the Mayo Clinic and University of Pittsburgh, USA.

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    for style and length.


    ========================================================================== Journal Reference:
    1. Nicola Cosgrove, Damir Vareslija, Stephen Keelan, Ashuvinee
    Elangovan,
    Jennifer M. Atkinson, Sine'ad Cocchiglia, Fiona T. Bane, Vikrant
    Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart,
    Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi
    Oesterreich, Adrian V.

    Lee, Fergus J. Couch, Leonie S. Young. Mapping molecular subtype
    specific alterations in breast cancer brain metastases identifies
    clinically relevant vulnerabilities. Nature Communications, 2022;
    13 (1) DOI: 10.1038/s41467-022-27987-5 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/01/220128100747.htm

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