New study suggests two paths toward 'super immunity' to COVID-19
Research compares routes to immunity involving vaccination

Date:
January 25, 2022
Source:
Oregon Health & Science University
Summary:
New laboratory research reveals more than one path toward robust
immunity from COVID-19. A new study finds that two forms of immunity
- - breakthrough infections following vaccination or natural
infection followed by vaccination -- provide roughly equal levels of
enhanced immune protection. The research follows an earlier study
that described extremely high levels of immune response following
breakthrough infections -- so-called 'super immunity.' That study
was the first to use multiple live SARS-CoV-2 variants to measure
cross-neutralization of blood serum from breakthrough cases.



FULL STORY ==========================================================================
New laboratory research from Oregon Health & Science University reveals
more than one path toward robust immunity from COVID-19.


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A new study finds that two forms of immunity -- breakthrough infections following vaccination or natural infection followed by vaccination --
provide roughly equal levels of enhanced immune protection.

The new study published online today in the journal Science Immunology.

"It makes no difference whether you get infected-and-then-vaccinated,
or if you get vaccinated-and-then-a-breakthrough infection," said
co-senior author Fikadu Tafesse, Ph.D., assistant professor of molecular microbiology and immunology in the OHSU School of Medicine. "In either
case, you will get a really, really robust immune response -- amazingly
high." The research follows an OHSU study published in December that
described extremely high levels of immune response following breakthrough infections - - so-called "super immunity." That study was the first to
use multiple live SARS-CoV-2 variants to measure cross-neutralization
of blood serum from breakthrough cases.

The new study found that it doesn't matter whether someone gets a
breakthrough infection or gets vaccinated after a natural infection. In
both cases, the immune response measured in blood serum revealed
antibodies that were equally more abundant and more potent -- at least
10 times more potent -- than immunity generated by vaccination alone.



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The study was done before the emergence of the omicron variant, but
researchers expect the hybrid immune responses would be similar with
the new highly transmissible variant.

"The likelihood of getting breakthrough infections is high because there
is so much virus around us right now," Tafesse said. "But we position
ourselves better by getting vaccinated. And if the virus comes, we'll
get a milder case and end up with this super immunity." Researchers
recruited a total of 104 people, all OHSU employees who were vaccinated
by the Pfizer vaccine, and then carefully divided them into three groups:
42 who were vaccinated with no infection, 31 who were vaccinated after an infection, and 31 who had breakthrough infections following vaccination.

Controlling for age, sex and time from vaccination and infection, the researchers drew blood samples from each participant and exposed the
samples to three variants of the live SARS-CoV-2 virus in a Biosafety
Level 3 lab on OHSU's Marquam Hill campus.

They found both of the groups with "hybrid immunity" generated greater
levels of immunity compared with the group that was vaccinated with
no infection.

A path toward endemic COVID With the wildly contagious omicron variant
now circulating across the globe, the new findings suggest each new breakthrough infection potentially brings the pandemic closer to the end.



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"I would expect at this point many vaccinated people are going to wind
up with breakthrough infections -- and hence a form of hybrid immunity,"
said senior co-author Bill Messer, M.D., Ph.D., assistant professor of molecular microbiology and immunology and medicine (infectious diseases)
in the OHSU School of Medicine Over time, the virus will run into an ever-expanding pool of human immunity.

OHSU scientists say they haven't tested multiple rounds of natural
infection, although many people will likely find themselves in that
category given that millions of people in the United States and around
the world remain entirely unvaccinated. With the spread of the highly contagious omicron variant, many unvaccinated people who were previously infected are likely to confront the virus again.

For that group, previous research reveals a much more variable level of
immune response than vaccination, Messer said.

"I can guarantee that such immunity will be variable, with some people
getting equivalent immunity to vaccination, but most will not," he
said. "And there is no way, short of laboratory testing, to know who
gets what immunity.

Vaccination makes it much more likely to be assured of a good immune
response." Senior co-author Marcel Curlin, M.D., agreed.

"Immunity from natural infection alone is variable. Some people produce
a strong response and others do not," said Curlin, associate professor
of medicine (infectious diseases) in the OHSU School of Medicine and
director of OHSU Occupational Health. "But vaccination combined with
immunity from infection almost always provides very strong responses.

"These results together with our previous work point to a time
when SARS-CoV- 2 may become a mostly mild endemic infection like a
seasonal respiratory tract infection instead of a worldwide pandemic."
In addition to Tafesse, Messer and Curlin, co-authors included Timothy
Bates, Savannah McBride, Hans Leier, Gaelen Guzman, Zoe Lyski, Devin
Schoen, Bradie Winders, Joon-Yong Lee of the Pacific Northwest National Laboratory and David Xthona Lee.

The study was funded by a grant from the M.J. Murdock Charitable Trust;
an unrestricted grant from the OHSU Foundation; the National Institutes
of Health, training grant T32HL083808 and grant R01AI145835; and OHSU Innovative IDEA grant 1018784.

The study authors acknowledge the research participants for their
generous contributions; OHSU's COVID-19 serology study team and the OHSU Occupational Health Department for recruitment and sample acquisition;
and the OHSU clinical laboratory under the direction of Donna Hansel,
M.D., Ph.D., and Xuan Qin, Ph.D., for SARS-CoV-2 testing and reporting.

========================================================================== Story Source: Materials provided by
Oregon_Health_&_Science_University. Original written by Erik
Robinson. Note: Content may be edited for style and length.


========================================================================== Journal References:
1. Timothy A. Bates, Savannah K. McBride, Hans C. Leier, Gaelen
Guzman, Zoe
L. Lyski, Devin Schoen, Bradie Winders, Joon-Yong Lee,
David Xthona Lee, William B. Messer, Marcel E. Curlin,
Fikadu G. Tafesse. Vaccination before or after SARS-CoV-2
infection leads to robust humoral response and antibodies that
effectively neutralize variants. Science Immunology, 2022; DOI:
10.1126/sciimmunol.abn8014
2. Timothy A. Bates, Savannah K. McBride, Bradie Winders, Devin Schoen,
Lydie Trautmann, Marcel E. Curlin, Fikadu G. Tafesse. Antibody
Response and Variant Cross-Neutralization After SARS-CoV-2
Breakthrough Infection.

JAMA, 2022; 327 (2): 179 DOI: 10.1001/jama.2021.22898 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/01/220125112524.htm

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