Antifreeze cream prevents frostbite injuries to skin, study suggests
Date:
January 19, 2022
Source:
American Chemical Society
Summary:
Skiers, hikers, soldiers and others exposed to extreme cold
temperatures can experience frostbite -- a painful injury that
occurs when ice crystals form in the skin. Many extremely cold areas
are also remote, and delays in frostbite treatment can result in
severe wounds, scarring and even limb amputation. Now, researchers
have developed a cream that prevents frostbite injuries in mice
when applied to the skin 15 minutes before severe cold exposure.
FULL STORY ========================================================================== Skiers, hikers, soldiers and others exposed to extreme cold temperatures
can experience frostbite -- a painful injury that occurs when ice crystals
form in the skin. Many extremely cold areas are also remote, and delays
in frostbite treatment can result in severe wounds, scarring and even
limb amputation. Now, researchers reporting in ACS Applied Biomaterials
have developed a cream that prevents frostbite injuries in mice when
applied to the skin 15 minutes before severe cold exposure.
========================================================================== Frostbite not only kills skin cells, but can also harm deeper tissues like muscle and bone, sometimes causing secondary infections and permanent
nerve damage. Common therapies, such as rapid rewarming of the affected
limb, aim to reverse tissue freezing, but by the time of treatment, many
cells have already died. Recently, scientists have developed frostbite prevention strategies, such as electric heaters sewn into clothing or transgenic antifreeze proteins, but such approaches are often costly, impractical or have safety concerns.
Therefore, Munia Ganguli and colleagues wanted to test the frostbite
prevention properties of a combination of synthetic molecules commonly
used in labs to cryopreserve cells. Dimethyl sulfoxide (DMSO) keeps
ice crystals from forming inside cells, whereas poly(vinyl alcohol)
(PVA) prevents ice crystals in the spaces between cells, which can
damage membranes.
The researchers first tested the ability of different amounts of DMSO
and PVA, alone or in combination, to prevent the death of cultured cells
in a dish that were exposed to a freezing temperature. They found that
2% DMSO combined with 1.6 mg/mL PVA yielded the highest cell survival
(about 80%), while protecting the cell membrane and cytoskeleton. This combination, which the researchers called SynAFP, also allowed cells
to divide and express proteins more normally after cold stress. Then,
the team mixed SynAFP with a commercial aloe vera cream and applied it
to the skin of mice 15 minutes before a cold challenge.
The cream reduced frostbite wound size, tissue damage and inflammation,
and sped healing, compared with no treatment. The cream did not prevent frostbite when applied 30 minutes or more before the cold challenge;
however, multiple applications did not damage skin. The effects of the antifreeze cream in people, and how frequently it needs to be reapplied,
must still be determined, the researchers say.
The authors acknowledge funding from the Defence Research and Development Organisation, the Department of Biotechnology Junior Research Fellowship
and the Council of Scientific & Industrial Research (CSIR).
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Content may be edited for style and length.
========================================================================== Journal Reference:
1. Aanchal Gupta, Betsy Reshma G, Praveen Singh, Ekta Kohli, Shantanu
Sengupta, Munia Ganguli. A Combination of Synthetic Molecules Acts
as Antifreeze for the Protection of Skin against Cold-Induced
Injuries. ACS Applied Bio Materials, 2021; 5 (1): 252 DOI:
10.1021/acsabm.1c01058 ==========================================================================
Link to news story:
https://www.sciencedaily.com/releases/2022/01/220119090851.htm
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