Lower chance of pregnancy and childbirth after IVF with one ovary

Date:
March 8, 2022
Source:
Karolinska Institutet
Summary:
Women who have had one ovary surgically removed (unilateral
oophorectomy) are less likely to become pregnant after in vitro
fertilization and give birth to fewer babies than women with both
ovaries. That is according to an extensive meta-analysis.



FULL STORY ========================================================================== Women who have had one ovary surgically removed (unilateral oophorectomy)
are less likely to become pregnant after in vitro fertilisation and give
birth to fewer babies than women with both ovaries. That is according
to an extensive meta-analysis published in the journal Fertility and
Sterility by researchers at Karolinska Institutet in Sweden.


========================================================================== Whether women's fertility is affected by the removal of one ovary has
been subject to inconclusive data. It was previously believed that
the remaining ovary could compensate for the loss in women undergoing
treatment with IVF and researchers at Karolinska Institutet have now interrogated the question through a meta-analysis.

"Our meta-study shows that a successful IVF outcome was less likely in
women that have only one ovary, compared with women with both intact
ovaries," says Kenny Rodriguez-Wallberg, adjunct professor at the
Department of Oncology- Pathology, Karolinska Institutet, and consultant
at Karolinska University Hospital. "We have been able to show, for the
first time, that the surgical removal of an ovary has an adverse effect
on fertility." When conducting a meta-study, researchers review published studies to compare their results against their own point of inquiry. In
this present study, the researchers identified more than 3,000 papers
on the subject, of which 18, published between 1984 and 2018, met their criteria and were selected for the final analysis. Taken together, the
papers included 1,057 IVF attempts for women with one ovary and 45,813
for women with two. Five of the studies were included in the analyses
of live births, 15 in the analysis of pregnancy rate.

In the group of women with one ovary, the chance of giving birth and of becoming pregnant were both around 30 per cent lower than in the group
of women with both ovaries.

"We need to realise the consequences on fertility of removing one ovary,"
says Kenny Rodriguez-Wallberg. "Sometimes, the operation is necessary,
in the event, say, of a malignant tumour, but it's important to improve
the information we give to women about what it can mean for their chances
of having future children. Given that the biological reserve of eggs is
already limited, we should, in some cases, also offer these women the opportunity to freeze their eggs ahead of an oophorectomy." One reason
for the previous belief that fertility was unaffected is that most of
the studies carried out were too small to provide a significant result.

The researchers now want to examine if the surgical removal of an ovary
has any other health effects, such as the impact that the reduced hormone production might have on the development of other diseases.

The study was financed by the Swedish Research Council, the Swedish
Cancer Society, the Swedish Childhood Cancer Foundation, the Cancer
Research Funds of Radiumhemmet and Region Stockholm.


========================================================================== Story Source: Materials provided by Karolinska_Institutet. Note: Content
may be edited for style and length.


========================================================================== Journal Reference:
1. Kenny A. Rodriguez-Wallberg, Hanna P. Nilsson, Tekla Lind. Live
birth and
pregnancy rates after in vitro fertilization/intracytoplasmic
sperm injection in women with previous unilateral oophorectomy:
a systematic review and meta-analysis. Fertility and Sterility,
2022; DOI: 10.1016/ j.fertnstert.2022.01.033 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2022/03/220308102752.htm

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