• MRI sheds light on COVID vaccine-associa

    From ScienceDaily@1:317/3 to All on Tue Feb 15 21:30:40 2022
    MRI sheds light on COVID vaccine-associated heart muscle injury

    Date:
    February 15, 2022
    Source:
    Radiological Society of North America
    Summary:
    Vaccine-associated myocarditis shows a similar injury pattern
    on cardiac MRI compared to other causes of myocarditis, but
    abnormalities are less severe, according to a new study.



    FULL STORY ========================================================================== Vaccine-associated myocarditis shows a similar injury pattern on cardiac
    MRI compared to other causes of myocarditis, but abnormalities are less
    severe, according to a new study published in the journal Radiology.


    ========================================================================== Myocarditis, or inflammation of the heart muscle, often occurs as a result
    of a viral infection, including COVID-19. It can affect the heart's rhythm
    and ability to pump blood and may leave behind lasting damage in the form
    of scarring of the heart muscle. Myocarditis has also been reported as
    a rare complication of the messenger RNA (mRNA)-based COVID-19 vaccines.

    Cardiac MRI has an important role in the assessment of acute myocarditis
    with unparalleled ability for noninvasive characterization of myocardial tissue.

    Understanding the pattern and extent of myocardial injury and its
    implications will allow for improved care of these patients and may help
    to address vaccine hesitancy.

    Therefore, cardiac radiologist Kate Hanneman, M.D., M.P.H., and colleagues
    at University Health Network, University of Toronto, set out to determine
    the pattern and extent of cardiac MRI findings in myocarditis associated
    with COVID-19 vaccination and to compare these findings to other causes
    of myocarditis, including COVID-19.

    "We know that the risk of myocarditis following COVID-19 vaccination
    is very low. However, there is very limited data on the extent of
    injury in the heart in comparison to other causes of myocarditis,"
    Dr. Hanneman said.

    For this retrospective study, the researchers analyzed data from
    92 consecutive adult patients with myocarditis and abnormalities on
    cardiac MRI performed at a tertiary referral hospital between 2019 and
    2021. Patients were classified into one of three groups: myocarditis
    following COVID-19 vaccination, myocarditis following COVID-19 illness,
    and myocarditis not associated COVID-19 vaccination or illness.



    ==========================================================================
    Of the 92 patients, 21 (22%) had myocarditis following COVID-19
    vaccination (mean age 31 years). Ten patients (11%) had myocarditis
    following COVID-19 illness (mean age 51 years), and 61 (66%) had other myocarditis (mean age 44 years). Patients with myocarditis following vaccination were younger and more frequently male compared to the
    other groups.

    Chest pain occurred in all 21 patients with vaccine-associated
    myocarditis. The pain started one to seven days after vaccination and
    lasted one to six days.

    Fourteen of the patients (67%) were admitted to hospital with a median
    length of stay of 3 days. No patients were admitted to the intensive
    care unit.

    Troponin levels were elevated in all patients admitted to hospital and substantially decreased in all by the time of discharge.

    MRI findings in vaccine associated myocarditis included late
    gadolinium enhancement in 17 (81%) and left ventricular dysfunction in 6
    (29%). Cardiac MRI showed that, compared with other causes of myocarditis, patients with vaccine-associated myocarditis had less functional
    impairment and less extensive myocardial abnormalities. Patients
    with COVID-19 illness and other myocarditis had a higher prevalence of abnormalities involving the interventricular septum and worse myocardial
    injury measured by T1 mapping.

    At short-term follow-up (median 22 days), all patients with
    vaccine-associated myocarditis were asymptomatic with no adverse events.

    "These results tell us that myocarditis following COVID-19 vaccination
    tends to be relatively mild and resolves quickly," Dr. Hanneman said.

    First author and cardiac imaging fellow, Matteo Fronza, M.D., said that resolution of all symptoms and lack of adverse events at follow-up is reassuring. However, longer-term follow-up is needed.

    The researchers emphasized that COVID-19 illness can result in myocardial injury that is associated with adverse outcomes in hospitalized patients,
    and this consideration should be balanced against the low risk of vaccine-related complications.

    "Not only is myocarditis following COVID-19 vaccination very rare,
    it also tends to be less severe than myocarditis following SARS-CoV2 infection," Dr.

    Hanneman said.

    Co-investigator and cardiologist, Paaladinesh Thavendiranathan,
    M.D., S.M., agrees. "Patients should not avoid COVID-19 vaccination
    for fear of myocarditis," he said. "The risk of myocarditis
    seems to be much higher following COVID-19 illness. However,
    if patients do experience symptoms - - especially chest pain --
    early after COVID-19 vaccination, they should seek medical attention." ========================================================================== Story Source: Materials provided by
    Radiological_Society_of_North_America. Note: Content may be edited for
    style and length.


    ========================================================================== Journal Reference:
    1. Matteo Fronza, Paaladinesh Thavendiranathan, Victor Chan, Gauri Rani
    Karur, Jacob A. Udell, Rachel M. Wald, Rachel Hong, Kate Hanneman.

    Myocardial Injury Pattern at MRI in COVID-19 Vaccine-associated
    Myocarditis. Radiology, 2022; DOI: 10.1148/radiol.212559 ==========================================================================

    Link to news story: https://www.sciencedaily.com/releases/2022/02/220215102839.htm

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